After saving countless planets from dreadful doom and earning intergalactic mega-celebrity status in the process, Ratchet and Clank have taken some well-deserved R&R - again. Yet, Ratchet remains restless. An orphan of the universe, he has never known anything of his past, his family, or his Lombax origins. And no one, not even Clank, can fill that void.

Unfortunately for Ratchet, someone else is equally interested in Ratchet’s origins: Emperor Percival Tachyon. In his thirst for revenge, the vile tyrant of an ancient race of foul insect-like monsters called Cragmites has festered an age-old grudge and is bent on wiping the last-known Lombax off the universe. As Tachyon’s forces ambush Ratchet and Clank in their home galaxy, our heroes realize they need to escape quickly to prevent its destruction. In a move of desperate irony, Ratchet and Clank steal Tachyon’s imperial warship and embark upon an adventure bigger than any they’ve experienced- one that will not only unravel the mystery of the Lombaxes, but also test the very limits of their friendship.