In this latest installment of the wildly popular franchise, players are reacquainted with Leon S. Kennedy, Raccoon City's idealistic rookie cop from Resident Evil 2. In the six years since the destruction of Raccoon City, the U.S. government has been able to destroy the nefarious Umbrella Corporation.

Fast forward to 2005 and players rejoin Leon, now a U.S. agent with a top-secret mission. His investigation into the abduction of the President's daughter has led him to a mysterious location in Europe teeming with unimaginable horrors.