Bart vs. The Space Mutants is a platform game where you play the role of Bart Simpson (from the TV show The Simpsons) and must stop the Space Mutants from invading Springfield. On each of the five levels, Bart must collect (or get rid of) the ingredients that the Space Mutants are planning to use to build their
machine, such as purple objects or balloons. If he collects enough "proof" of the aliens existence (left behind when they are jumped on), his family members help him when he meets a boss (characters such as Nelson and Sideshow Bob).