Teenage Mutant Ninja Turtles: The Hyperstone Heist is a Side-scrolling beat em up based on the Teenage Mutant Ninja Turtles (TMNT) franchise, and was also the first TMNT game released for the Sega Mega Drive/Genesis. This game was known as Teenage Mutant Ninja Turtles: The Hyperstone Heist in the United States, as Teenage Mutant Hero Turtles: The Hyperstone Heist in Europe, and as Teenage Mutant Ninja Turtles: Return of the Shredder in Japan.

A redesigned version of Teenage Mutant Ninja Turtles: Turtles in Time, the time travel concept was removed from this version and replaced by a plot where Shredder uses the Hyperstone to shrink Manhattan Island to the size of a bottle. Several of the stages of the original arcade game are used, with their odd, non-modern appearance explained away for example, the pirate ship becomes a ghost ship.