The Mushroom Kingdom is stricken with a horrible disease known as 'The Blorbs'! Princess Toadstool calls a meeting to discuss what action must be taken to save her citizens, and of course, Mario and Luigi attend. Bowser crashes the
meeting, but is soundly defeated once again. After he's evicted from the castle, he meets a shady character who offers him a mysterious mushroom that he promises will beat Mario once and for all. Wolfing it down, Bowser suddenly starts sucking in everything in sight - including all of the Mushroom Kingdom's citizens, and the famous brothers themselves! What troubles will strike the kingdom next?