The evil Him has done it again. The Powerpuff girls are on a harmless scavenger hunt until the evil Him causes mayhem throughout Townsville. He steps in with his own version of the game to spice things up. You need to teach Him a lesson once and for all. Guide any of the Powerpuff Girls, Blossom, Bubbles or Buttercup, as they kick, fly, punch and use the rest of their powers to vanquish anything that stands in their way.