The Powerpuff Girls come to life in this cartoon fighting game for the N64. Mojo Jojo has stolen pies full of Chemical X from the Powerpuff Girls and given a piece to every villain in town. It's up to kids to team up with the pint sized heroes, Bubbles, Buttercup, and Blossom and fight each of the Townsville Villains to get all of the Chemical X back.