An Egyptian artifact protected by a deadly curse has been abducted from a museum in Curse: The Eye of Isis. As archaeologist Darien Dane, players must recover the statuette and return it to its original resting place in Egypt. Together with his assistant Verity, Dane must travel by train, cargo steamship, and through an ancient pyramid to break the evil curse once and for all. Until the statuette is returned, players must be prepared to battle mummies and other creatures while solving a variety of puzzles. A number of 3D animated cut-scenes further the story as players encounter an assortment of characters during the perilous journey.