Three more monsters have been created by a radioactive goop. Now, they want to free their friends who have been captured. You take the role of either Boris, a strong Rhino; Ruby, a quick lobster; or Curtis, a well-balanced rat. In order to free George, Lizzy, and Ralf (the characters from the original game) you will have to travel to New York, Tokyo, and London. Along the way, you will have to destroy building and avoid the human defenses in 25 levels of smashing action. As the game progresses, full-motion video segments explain the storyline. You can have two of your friends join the action via a multitap. Will the new monsters be able to rescue their friends? You can help them by playing RAMPAGE 2: Universal Tour.